Table 1.
Clinical and demographic characteristics of included subjects.
Figure 1.
Regional Homogeneity (ReHo) Analysis in Asymptomatic GRN+ carriers (aGRN+) compared to young healthy controls (yHC), showing reduced ReHo index (Panel A) as well as increased ReHo index (Panel B).
The results are superimposed on a 3D-standarized T1 brain template. P<0.01 uncorrected, p<0.05 FDR cluster-level. L = left.
Table 2.
Alterations of brain connectivity parameters in asymptomatic GRN carriers as compared to healthy controls.
Figure 2.
Regional Homogeneity (ReHo, Panel A), Fractional Amplitude of Low Frequency Fluctuations (fALFF, Panel B), Degree Centrality (DC, Panel C) analyses in Frontotemporal Dementia related to GRN (FTD-GRN+) compared to old healthy controls (oHC) using Biological Parametric Mapping Analysis (BPM) showing either reduced and increased significant clusters.
The results are superimposed on a 3D-standarized T1 brain template. P<0.01 uncorrected, p<0.05 FDR cluster-level. L = left.
Table 3.
Alterations of brain connectivity parameters in FTD-GRN+ as compared to healthy controls.
Figure 3.
Effect of age on Regional Homogeneity (ReHo, Panel A), Fractional Amplitude of Low Frequency Fluctuations (fALFF, Panel B) and Degree Centrality (DC, Panel C) in GRN+ subjects (aGRN+ and FTD-GRN+) compared to healthy controls (yHC and oHC) (difference of slope analysis).
The results are superimposed on a 3D-standarized T1 brain template. P<0.01 uncorrected, p<0.05 FDR cluster-level. L = left. Panel D: presentation of all previous results at a more stringent threshold (p<0.001 uncorrected, p<0.05 FWE cluster-level), superimposed on an axial T1 brain template.
Table 4.
Effect of age on multimodal connectivity measures in GRN+ subjects (aGRN+ and FTD-GRN+) compared to healthy controls (difference of slope analysis).