Figure 1.
Pre-Treatment (Post-Challenge) and Post-Treatment Mean PA levels in Sera from Study 1 Rabbits.
New Zealand white rabbits were exposed to 200×LD50 doses of aerosolized B. anthracis spores and serum collected at different time points Post-Challenge (A) and Post-Infusion (B) was tested by electro-chemiluminiscence (ECL) assay for detection and quantitation of B. anthracis protective antigen (PA). Animals received combination treatment with Placebo+ levofloxacin or AIGIV + levofloxacin at 30, 36, 48 and 60 hours post-exposure. AIGIV was given IV as a slow infusion at 15 U/kg of body weight and levofloxacin at 50 mg/kg given orally once a day for 3 days. PI = Post-Infusion PC = Post-Challenge.
Table 1.
Summary of mean time to death and survival of rabbits in two sequential combination treatment studies.
Table 2.
Effect of combination treatment on incidence of bacteremia and toxemia in study 1.
Table 3.
Effect of combination treatment on incidence of bacteremia in study 2.
Table 4.
Effect of combination treatment on incidence of toxemia in study 2.
Figure 2.
Pre-Treatment Mean PA levels in Sera from Study 2 Rabbits.
New Zealand white rabbits were exposed to 200×LD50 doses of aerosolized B. anthracis spores and serum collected at different time points was tested by electro-chemiluminiscence (ECL) assay for detection and quantitation of B. anthracis protective antigen (PA). PI = Post-Infusion PC = Post-Challenge.
Figure 3.
Post-Treatment Mean PA levels in Sera from Study 2 Rabbits.
Animals received combination treatment with Placebo+ levofloxacin or AIGIV + levofloxacin at 60, 72, 84 and 96 hour post-exposure. AIGIV was given IV as a slow infusion at 15 U/kg of body weight and levofloxacin at 50 mg/kg given orally once a day for 3 days. The levels of PA were significantly reduced (P<0.05; ANOVA model and Wilcoxon rank sum test) following treatment with AIGIV and levofloxacin compared to treatment with IGIV and levofloxacin. PI = Post-Infusion PC = Post-Challenge.