Figure 1.
Morphological comparison and schematic diagram of mammalian limbs.
(A, B) Morphology of adult mouse (M. musculus) and bat (M. schreibersii) limbs. FDI, FDII, FDIII, FDIV and FDV: forelimb digits I, II, III, IV and V; HD: Hindlimb digits; Cal: calcar. (C) Schematic diagram of bat, mouse, human and whale limbs. The various colors indicate bones of various groups Scale bars, 2 cm in (A–B).
Figure 2.
Comparison of the expression levels of Meis2, Mab21l2 in mRNA-Seq samples at bat embryonic stages 15–17.
FI: forelimb digit I; FW: interdigital tissues between forelimb digits I and II; FD: elongating forelimb digits II–V; FF: interdigital tissues between forelimb digits II and V; HD: hindlimb digits I–V; HW: interdigital tissues between hindlimb digits I and V.
Figure 3.
Meis2 expression in the fore- (F) and hindlimbs (H) of embryonic bats and mice visualized by WISH.
All images are the dorsal view with anterior pointing up.S14L: Late stage14; S17M: Middle stage 17; S19E: Early stage 19; Scale bars, 200 µm in (A–L) and 500 µm in (M–X).
Figure 4.
Mab21l2 expression in the fore- (F) and hindlimbs (H) of embryonic bats and mice visualized by WISH.
Each stage is shown with dorsal (D) and ventral (V) views. Anterior is up in all images. Scale bar, 200 µm.
Figure 5.
Tbx3 expression in the fore- (F) and hindlimbs (H) of embryonic bats visualized by WISH.
All images are the dorsal view with anterior pointing up. Scale bar, 500 µm.