Figure 1.
Coronal T1-weighted, directionally-encoded color FA map and T2-weighted MR images obtained from middle-aged transgenic rat (A) and age-matched control rat (B).
White arrows point to enlarged ventricular size in the Tg rat. The red contour delineates the ROI selected for measurement of DTI parameters in the CC.
Table 1.
Quantitative measurements of Neu-N counts and GFAP and NFH staining intensities in the young and middle-aged animals, in various locations.
Figure 2.
Changes in (A) parenchymal volume and (B) ventricular volume, between the Tg rats and their age-matched controls at both young and middle-age.
Figure 3.
Changes in (A) CC fractional anisotropy and (B) CC mean diffusivity between the Tg rats and their age-matched controls at both young and middle-age.
Table 2.
Summary and Statistical Analysis of MR Measures in the Longitudinal Study.
Figure 4.
Immunofluorescence images from age-matched 3-month old Tg (A) and control (B) rats and from age-matched 7-month old Tg (C) and control (D) rats.
The captures were obtained from the central portion of the corpus callosum in each animal. Each row shows GFAP staining in yellow, NFH staining in Blue and a composite image of both (magnification 100X, scale bar = 40 µm). Subtle decreased GFAP and NFH staining are seen in the young Tg compared to the young control rat, however those differences become more noticeable in the 7-month old Tg compared to the age-matched control.