Figure 1.
Change of the APC sensitivity ratio during the study period.
Box-whisker plots show the ratio [ETP+APC/ETP−APC] at visits 1–4. The center horizontal solid line is drawn at the median. Top and bottom edges of the boxes are located at the sample 75th and 25th percentiles. Top and bottom of the whiskers are located at the 90th and 10th percentiles. Each outlier is shown. P values indicate the changes of visits 2–4 compared to visit 1.
Figure 2.
A. Thrombin plasma levels, determined by OECA; Limit of quantification (LOQ, solid line), 0.039 ng/ml; Limit of detection (LOD, dotted line), 0.017 ng/ml. B. APC plasma levels, determined by OECA; LOQ (solid line), 0.116 ng/ml; LOD (dotted line), 0.022 ng/ml.
Figure 3.
Changes of variables during the study period.
Columns show the median. Parameters with significant changes between visit 1 and visit 4 are listed. P values indicate the changes of visits 2–4 compared to visit 1. *indicates highly significant changes of p<0.005.