Figure 1.
Characterization of tandem RNA chimeras.
Barplot representing the frequency of the predicted structural classes for all tandem RNA chimeras. The most prevalent observed class is a promoter swap event.
Figure 2.
Distances between chimeric partner genes.
Shown are distances between the tandem RNA chimeric partner genes in Mb. The majority of the distances are in the range between 5 kb and 170 kb.
Figure 3.
Tandem RNA chimeras frequency plots in five human populations.
All populations show similar patterns with most of the chimeric transcripts found only in a few individuals.
Figure 4.
Venn diagrams displaying the relations between tandem RNA chimeras in five human populations (A); intrachromosomal chimeras located on different strands (B); and interchromosomal chimeras (C).
Figure 5.
Plot showing the proportions of the exon exclusion patterns in the tandem RNA chimeras. The numbers of the exons for the 5′ partner gene are counted from last to first, while the numbers of the exons for the 3′ partner gene are counted from first to last. The most abundant exon exclusion pattern involves the exclusion of the terminal exon of the 5′ partner gene and the first exon of the 3′ partner gene.
Figure 6.
Expression level distributions of tandem RNA chimeras and their partner genes.
RNA chimeras are lower expressed than their partner genes.
Figure 7.
Density plots showing the distributions of the fusion 5′ and 3′ introns length versus the length of the rest of the introns comprising the fusion partner genes. Observed is a notable higher proportion of larger introns at the breakpoint.
Table 1.
The most significant SNPs associated with RNA chimeras formation.