Figure 1.
Aniracetam treatment did not alter locomotion in the open field.
(A) Control mice and mice given aniracetam did not show a difference in total distance moved in an open field test. (B) Control mice and mice given aniracetam did not show a difference in total distance moved in the center of the open field test. Graphs show the mean (± SEM). n = 15 per group.
Figure 2.
Aniracetam treatment did not alter performance in the elevated plus maze test.
(A) Control mice and mice given aniracetam did not show a difference in time in the open, center, or closed arms in the 10 minute trial in the elevated-plus maze test. (B) Control mice and mice given aniracetam did not show a difference in number of visits in the open arm, center arm, or closed arm in the 10 minute trial in the elevated-plus maze test. Graphs show the mean (± SEM). n = 15 per group.
Figure 3.
Aniracetam treatment did not alter motor learning in the accelerating rotarod test.
(A) Control mice and mice given aniracetam did not show a difference in their ability to remain on an accelerating rotarod across 8 trials. Graphs show the mean (± SEM). n = 15 per group.
Figure 4.
Aniracetam treatment did not alter spatial navigation in the Morris water maze test.
(A) Control mice and mice given aniracetam did not show a difference in their ability to find a hidden platform across the 8 trials. We measured the path length traveled to find the hidden platform. (B) Control mice and mice given aniracetam did not show a difference in their ability to find a hidden platform across the 8 trials. We measured the latency to find the hidden platform. (C) Control mice and mice given aniracetam did not show a difference in their ability to find a visible platform. Graphs show the mean (± SEM). n = 15 per group.
Figure 5.
Aniracetam treatment did not alter repetitive behaviors in the marble burying test.
(A) Control mice and mice given aniracetam did not show a difference in their ability to bury marbles in a 30 minute test trial. Graphs show the mean (± SEM). n = 15 per group.
Figure 6.
Aniracetam treatment did not alter fear conditioning.
(A) Control mice and mice given aniracetam did not show a difference in their ability to learn to associate a novel tone with an aversive stimulus (mild shock). (B) We then examined their ability to remember this association 24 hours later. There was no difference between the groups in terms of freezing in a novel context and there was no difference in freezing to the conditioned stimulus when it was presented over the 3 minute trial. Graphs show the mean (± SEM). n = 15 per group.
Figure 7.
Aniracetam treatment did not alter learning in the odor discrimination test.
(A) We used odor discrimination to probe. The dependent measures were the time to target odor and the frequency of errors (errors were defined as interacting with the wrong cup and encountering but not eating from the target cup. There was no significant difference between the learning curves of the control and drug groups (A and B).