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Table 1.

Primers used for detecting the target genes and the melting temperatures (Tm) used for primers.

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Table 2.

Plasmids and PCR fragments used as standards.

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Figure 1.

Raw gene copy numbers detected in a WWTP sample (copy number/ml).

A - 16S rRNA gene in inflow (IF) and effluent (EF). Assay1 was used only for samples from large WWTP (Helsinki) from Winter 2010 to Autumn 2011; B–Antibiotic resistance genes (ARGs). Statistical significance between inflow wastewater and effluent samples: *** - p<0.01; *0.03>p>0.01. For the pairs not marked the statistical difference between inflow and outflow was statistically insignificant. The line in each box marks the median and boxes: 25th and 75th percentiles; whiskers: 5th and 95th percentiles and outliers ±1.5 * IQR. See Figure S2 in File S1 for abundances of same genes presented by each sampling event.

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Figure 1 Expand

Table 3.

Detection of ARGs in different WWTPs (total of all analyses per gene, n = 15).

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Table 3 Expand

Figure 2.

Normalised ARG abundances.

Antibiotic resistance gene copy numbers normalised to 16S rRNA gene copy numbers. The results are given for all samples for one gene for a WWTP, no seasonal comparison. Statistically significant comparison results are marked with *** at p<0.01, *0.03>p>0.01. The line in each box marks the median and boxes: 25th and 75th percentiles; whiskers: 5th and 95th percentiles and outliers ±1.5 * IQR.

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Figure 2 Expand