Figure 1.
TB Testing in the LPA and Xpert-based Algorithms.
The sequence of diagnostic tests in each algorithm and the action taken based on test results is shown. Shaded blocks indicate possible MDR-TB diagnostic points. Abbreviations: MDR-TB - multidrug-resistant tuberculosis; LPA - line probe assay; DST - drug susceptibility testing; HIV – human immunodeficiency virus; Rif – rifampicin; Pos – positi.
Figure 2.
MDR-TB cases identified from selected facilities and those included and excluded from the study and from the final analysis are shown. Abbreviations: MDR-TB – multidrug-resistant tuberculosis; DST- drug susceptibility test; TCT - treatment commencement time.
Table 1.
Comparison of Baseline Characteristics of MDR-TB Cases by Algorithm.
Figure 3.
Cumulative Time-to-event Plots by Algorithm.
Kaplan Meier time-to-event plots are shown for MDR-TB treatment commencement time (sample taken to treatment commencement) in Figure 3a and for laboratory turnaround time (to result available in the laboratory) in Figure 3b for cases included in the final analysis in the LPA- and Xpert-based algorithms. Abbreviation: MDR-TB - multidrug-resistant tuberculosis.
Table 2.
MDR-TB TCT, Laboratory Turnaround Time and Action Delay by Algorithm.
Figure 4.
Cumulative Time to MDR-TB TCT Plots for Co-variables Assessed by Algorithm.
Kaplan Meier time-to-event plots are shown for patient level variables assessed in the LPA-and Xpert-based algorithms: a) Sex; b) HIV-status; c) MDR-TB Risk Profile and d) MDR-TB Diagnostic Time-point. Inserts show Hazard Ratio (HR) for the univariate Cox regression analysis. Abbreviations: MDR-TB - multidrug-resistant tuberculosis; TCT – treatment commencement time.