Figure 1.
Serotype distribution of the isolates causing non-invasive pneumococcal pneumonia in adults in Portugal (1999–2011).
Only the overall 10 most frequent serotypes are shown. The other serotypes found between 1999 and 2011 were serotypes 6B, 7F and 15A (n = 32, each), 23B (n = 30), 15B (n = 28), 10A (n = 27), 9V and non-typable (n = 26, each), 23A (n = 24), 1 (n = 22), 8 (n = 20), 16F (n = 19), 29 (n = 18), 4 (n = 17), 31 (n = 16), 34 (n = 15), 18C (n = 14), 17F and 33A (n = 13, each), 21 and 35F (n = 11, each), 15C and 35C (n = 10, each), 20 (n = 9), 12B and 17A (n = 8, each), 13, 25F and 25A/38 (n = 7, each), 7C and 28A (n = 5, each), 5 (n = 4), 11F, 18A and 19C (n = 3, each), 12A, 12F, 35A, 35B, 38 (n = 2, each) and 9L, 10F, 15F, 16A, 19B, 33F, 39 and 42 (n = 1, each). The value shown for 1999–2003 refers to the yearly average of the 500 isolates studied that were isolated in these 5 years. This period was analyzed together since previously published IPD data indicated that these corresponded to a pre-PCV7 serotype distribution [14].
Figure 2.
Proportion of isolates expressing serotypes included in pneumococcal vaccines causing non-invasive pneumococcal pneumonia in adults in Portugal (1999–2011).
The value shown for 1999–2003 refers to the yearly average of the 500 isolates studied that were isolated in these 5 years. This period was analyzed together since previously published IPD data indicated that these corresponded to a pre-PCV7 serotype distribution [14].
Table 1.
Antimicrobial resistance of the isolates responsible for non-invasive pneumococcal pneumonia in adults in Portugal, stratified by age groups (1999–2011).
Table 2.
Serotype distribution of PNSP and ERP causing non-invasive pneumococcal pneumonia in adults in Portugal (1999–2011).
Figure 3.
Serotype distribution of the isolates causing non-invasive pneumococcal pneumonia and invasive pneumococcal disease in adults in Portugal (2009–2011).
Data from IPD were published previously [19]. Serotypes associated with NIPP or IPD are marked by asterisks. The odds ratio was used to measure the association between serotype and disease presentation and only significant values (P<0.05) after FDR correction are indicated. The P values for the serotypes associated with NIPP were: P = 0.001 for 19F, P = 0.007 for 6A, P = 0.004 for 11A, P = 0.001 for 15C, P<0.001 for 23B. The P values for the serotypes associated with IPD were: P = 0.007 for 4, P<0.001 for 14, P<0.001 for 1 and P<0.001 for 7F.