Figure 1.
ECDF of Pearson's pairwise correlations shown for 1000 random genes and 29 Epileptic Encephalopathy genes.
(A) Developing AHBA (B) Adult AHBA (C) Celsius resource.
Table 1.
Summary table detailing the |r| 5% significance cut-off values and the number of Epileptic Encephalopathy reference gene pairs reaching this cut-off from a total of n = 406 total gene pairs based on Pearson's correlation coefficient.
Figure 2.
Pairwise Pearson's correlations between pairs of known Epileptic Encephalopathy genes represented as a matrix.
(A) Adult AHBA correlation matrix with genes ordered according to the angular distance between the first two principal components. (B) Developing AHBA correlation matrix with genes ordered according to the angular distance between the first two principal components. (C) Developing AHBA correlation matrix with genes ordered according to the angular distance between the first two principal components based on the adult AHBA data. (D) Celsius derived correlation matrix with genes ordered according to the angular distance between the first two principal components of the adult AHBA.
Table 2.
The 19 candidate Epileptic Encephalopathy genes prioritized with connectivity measures (K) that met the 0.25 eFDR threshold for at least one of three different gene expression data resources (shown in bold) based on Pearson's correlation coefficient.
Figure 3.
Developing AHBA gene co-expression network and correlation matrix for known and prioritized Epileptic Encephalopathy genes.
Gene co-expression networks for the known Epileptic Encephalopathy genes in the top 5% of overall connections of the developing AHBA along with the 10 prioritized candidate Epileptic Encephalopathy genes (shown in blue) as determined by the connectivity measures that are estimated to have an eFDR = 0.25 (thresholded r) using qgraph (A) or represented as an ordered sample correlation (all r values) matrix (B) with ordering based on angular distance. See Figures S2 and S3 for adult AHBA and Celsius results respectively.