Figure 1.
Combined hippocampal and amygdala mask on sagittal planes.
Inter-group comparison of gray matter volume is performed within this mask. Left, left hemisphere; right, right hemisphere. The below numbers are the Montreal Neurological Institute coordinates on x axis.
Table 1.
Demographic information of the PTSD patients and controls.
Figure 2.
Reduced gray matter volumes of the bilateral hippocampi in PTSD patients.
A, the color clusters exhibit reduced gray matter volume of bilateral hippocampi in PTSD patients compared with controls (p<0.05, FDR correction). The upper numbers are the Montreal Neurological Institute coordinates on x axis. The colorbar represents the statistical value from 1 to 5. B, bar graph shows the gray matter volumes in bilateral hippocampal ROIs significantly reduced in PTSD patients compared with controls exhibiting strong effect sizes. ES, effect size.
Table 2.
Hippocampal clusters showed reduced gray matter volume in PTSD patients compared with controls.
Table 3.
Intergroup comparison of GMV in bilateral hippocampal ROIs.
Figure 3.
Gray matter volume (GMV) covariance of hippocampal ROIs with the ipsilateral amygdala in controls.
The color regions represent the clusters within the left (A) and right (B) amygdala in which GMV significantly co-varied with the ipsilateral hippocampal ROI (p<0.05, FDR corrected). The colorbar represents the statistical value. The below numbers are the Montreal Neurological Institute coordinates.
Figure 4.
Inter-group differences in gray matter volume (GMV) covariance of hippocampal ROIs with the ipsilateral amygdala.
The color regions represent the clusters within the left (A) and right (B) amygdala in which GMV covariance with the ipsilateral hippocampal ROI significantly decrease in PTSD patients compared with controls (p<0.05, FDR corrected). The colorbar represents the statistical value. The below numbers are the Montreal Neurological Institute coordinates.
Figure 5.
ROI-based correlation analyses of gray matter volumes between the bilateral hippocampal and amygdala ROIs.
ROI-based correlation analyses revealed that decreased structural covariance between the left hippocampal ROI and the left amygdala ROI (A), and between the right hippocampal ROI and the right amygdala ROI (B) in PTSD patients were attributed to a strong positive correlation in controls (left side: r = 0.776, p<0.001; right side: r = 0.568, p = 0.003) and no significant correlation in PTSD patients (left side: r = –0.205, p = 0.483; right side: r = –0.219, p = 0.453).