Figure 1.
Schematic illustration of the Safety Assessment Research Unit at AstraZeneca, Södertälje.
The unit comprised eight departments and performed preclinical toxicity studies and evaluations to support the company's various drug projects to predict potential side effects before e.g. clinical trials in man.
Table 1.
Projects related to improvements in study design, the reduction per study and estimated annual reduction.
Table 2.
Projects related to development of new methods, the reduction per study and estimated annual reduction.
Table 3.
Projects related to coordination, the reduction per study and estimated annual reduction.
Figure 2.
Total number of rats used in toxicity studies at the Safety Assessment Research Unit (black line) and total number of reported regulatory toxicity studies, one month or longer (black bars) and shorter investigative toxicity/mechanistic studies (grey bars) during the years 2006–2010.
Figure 3.
Estimated reduction in number of animals used in toxicity studies at Safety Assessment Research Unit.
Actual number of animals used in 2009 (black bars) compared with the estimated number of animals if no reduction projects would have been implemented (grey bars).
Figure 4.
Projects linked to the department ownership (a) or the participation (b) of each project.
The number of projects specified according to category of the project (a) and specified in relation to the participation in projects with multiple or single departments (b).