Table 1.
Baseline characteristics.
Figure 1.
Anti-HDV IgM values in the two cohorts.
Grouping into different IgM categories was performed as descripted in materials and methods.
Figure 2.
Distribution of ALT values according to Anti-HDV IgM categories in the HIDIT-2 cohort.
ALT values were significantly associated with the different anti-HDV IgM groups based on univariate ANOVA (p = 0.04) and univariate T- test in the HIDIT-2 cohort.
Figure 3.
Distribution of ALT values according to Anti-HDV IgM categories in the MHH cohort (only significant p-values).
The association of anti-HDV IgM and ALT was confirmed in the MHH cohort with significance over all groups of 0.03.
Figure 4.
Histological grading of the HIDIT-2 cohort.
Diagrammed% of patients with a HAI≥8 within the anti-HDV IgM groups.
Figure 5.
Histological staging of the HIDIT-2 cohort.
Diagrammed% of patients with cirrhosis (based on the classification indicated in material and methods) within the anti-HDV IgM groups.
Table 2.
Factors associated with anti-HDV IgM positive and negative values according to chi-square analysis in the HIDIT-2 cohort.
Table 3.
Factors associated with anti-HDV IgM positive and negative values according to chi-square analysis in the MHH cohort.
Figure 6.
Distribution of HBV values according to Anti-HDV IgM categories in the HIDIT-2 cohort.
HBV-DNA (log) is clearly associated with anti-HDV IgM indicated by ANOVA (p<0.01) and by T-test during the different IgM groups.
Figure 7.
Distribution of HBV values according to Anti-HDV IgM categories in the MHH cohort.
HBV-DNA levels were also lower in greater anti-HDV IgM groups in the MHH cohort although no differences could be observed within the anti-HDV IgM groups.
Table 4.
Factors univariatly associated with the groups of anti-HDV IgM based on ANOVA analysis.
Figure 8.
Factors associated with anti-HDV IgM based on univariate ANOVA testing in the HIDIT-2 cohort.
The dashed line indicated a p-value of 0.05. All parameters above the line were determined as significantly associated with the four anti-HDV IgM groups. Dots in blue indicate low levels of the value in greater anti-HDV IgM groups while orange dots represent parameters with high levels in a great anti-HDV IgM group shown at x axis.
Figure 9.
Cumulative event free survival of patients with anti-HDV IgM positive and negative values.