Table 1.
Co-inheritance of SCA-alpha thalassemia and of clinical events.
Table 2.
Hematological indices of SCA patients and controls (HbAA and HbAS).
Figure 1.
Co-inheritance of α-thalassemia among patients and controls.
Panel A displays a much higher prevalence of 3.7α-globin gene deletions among patients compared to unaffected controls [HbAA and HbSS combined (p = 0.003)]. This difference was mostly driven by a much lower proportion of 3.7 kb α-globin gene deletions among HbAA controls. Panel B displays the allele frequencies of the 3.7 kb α-globin gene deletions among patient and control. The frequencies were 22% among patients and 11.8% among controls (HbAS and HbAA combined) (p = 0.006). HbAS controls had more 3.7 kb α-globin gene deletions than HbAA controls (p = 0.02).
Table 3.
Co-inheritance of SCA and α-thalassemia and hematological indices.
Table 4.
Effects of α-thalassemia on key clinical and hematological indices, in generalised linear regression models, adjusted for age, sex and five SNPs* that influence HbF level.