Figure 1.
1a. The first question is “Symptoms1?”, “number 1″ refers to block 1 under the step diagram, in this block symptoms of heart failure are shown, so the user knows which symptoms could occur; When the answer is “NO”. 1b. Is the “EF<40%-20% or the FS<15%” YES grade 3 heart failure.
NO grade ≤2 heart failure. When the answer is “YES”
Go to question “Responsive to intervention2?” 2. Question “Responsive to intervention2?”, block 2 in which common interventions for heart failure are shown; When the answer is “NO”
grade 4 heart failure. When the answer is “YES”
grade 3 heart failure. When it is “UNKNOWN”
go to question “ Device3, life threatening consequences4 or heart transplant?”. 3. Question “ Device3, life threatening consequences4 or heart transplant?”, block 3 under the step diagram, in this block devices used as treatment for heart failure are shown. In block 4 the life threatening consequences associated with heart failure are stated; When the answer is “NO”
grade 3 heart failure. When the answer is “YES”
grade 4 heart failure. Ref. [10], [11]. ICD-10 = International classification of disease version 10. EF = ejection fraction. SF = shortening fraction. CRT-P or D = cardiac resynchronisation therapy pacemaker or defibrillator. ICD = implantable cardioverse defibrillator. LVAD = left ventricular assistance device.
Table 1.
Definitions of cardiac events (using CTCAEv3.0 and CTCAEv4.0).
Figure 2.
Methodology of testing the validity and consistency of the data-extraction form/flowchart method for CEs.
Table 2.
Result for validity (physician (P) vs non-physician (NP).
Table 3.
Result first consistency assessment (non-physician (NP) vs non-physician (brief introduction) (NPB)).
Table 4.
Result second consistency assessment (non-physician (NP) vs non-physician (extensive training) (NPE)).