Table 1.
List of Genes Assessed.
Table 2.
Dataset Clinical features.
Figure 1.
Box plot of pan-wildtype vs. K-ras mutation.
A) (Top Panel): Positive skewness with fine-texture significantly differentiates K-ras mutation from pan-wildtype (p = 0.031). B) (Bottom Panel): Lower kurtosis with coarse-texture significantly differentiates K-ras mutation from pan-wildtype (p = 0.009).
Figure 2.
Decision-tree for identification of KRAS mutations using QTA parameters.
M-Numbers of mutants; WT-number of pan-wildtype; SD-standard deviation; ssf-spatial scale factor.
Figure 3.
Overall survival curves based on QTA.
A) (Left Panel): Without filtration, higher skewness (green line, median OS 30.7 months) vs. lower skewness (blue line, median OS 89.4 months) was associated with inferior OS (p = 0.012). B) (Right Panel): Without filtration, lower kurtosis (green line, median OS 61.6 months) vs. higher kurtosis (blue line, median OS 93.2 months) was associated with inferior OS (p = 0.012).
Figure 4.
Disease free survival curves based on QTA.
Lower kurtosis with coarse-texture (green line, median DFS 59.6 months) had inferior OS vs. higher kurtosis (blue line, median DFS 93.2 months)(p = 0.048).