Figure 1.
Time course of the experiment.
CPT: cold pressor test. NWR: nociceptive withdrawal reflex.
Figure 2.
Thresholds before and after the cold pressor test (CPT).
Nociceptive withdrawal reflex (NWR) thresholds, electrical pain detection thresholds and pain intensity ratings to suprathreshold stimulation are shown for both sessions. **: p<0.01, ***: p<0.001.
Table 1.
Variations in the assessment measures due to conditioned pain modulation.
Figure 3.
Magnitude of the conditioned pain modulation effect (ΔCPM) for both sessions.
Assessment was performed with the nociceptive withdrawal reflex (NWR) thresholds, electrical pain detection thresholds and pain intensity ratings to suprathreshold stimulation.
Figure 4.
Bland-Altman plots of the magnitude of the conditioned pain modulation effect (ΔCPM).
Assessment was performed with the nociceptive withdrawal reflex (NWR) thresholds, electrical pain detection thresholds and pain intensity ratings to suprathreshold stimulation. The dashed line indicates the bias between sessions, whereas the dotted lines indicate the limits of agreement, calculated as ±1.96 times the standard deviation (SD) of the differences in measurements between sessions.
Table 2.
Reliability of the assessment measures before and during conditioned pain modulation.
Table 3.
Reliability of the conditioned pain modulation effect.
Table 4.
Hypothetical sample sizes of crossover () and parallel (
) experimental designs as a function of the effect size.