Figure 1.
Effects of eritoran on LPS-induced mRNA expression (arbitrary units) of TNFα (top left panel), CCL-2 (top right panel), IL-6 (middle left panel), IL-8 (middle right panel), VCAM (bottom left panel), and ICAM (bottom right panel).
Values reported as mean±SD (n = 5 per group). CT: control; ER: eritoran; LPS: lipopolysaccharide; ER/LPS: eritoran/lipopolysaccharide. *p<0.05 vs CT, ER, and LPS/ER.
Figure 2.
Effects of eritoran on OxPAPC-induced mRNA expression (arbitrary units) of IL-6 (top panel) and IL-8 (middle panel) and on FFA-induced mRNA expression (arbitrary units) of IL-6 (bottom panel).
Values reported as mean±SD (n = 5 per group). CT: control; ER: eritoran; OxPAPC: oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine; FFA: free fatty acids; OxPAPC/ER: oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine/eritoran. Top panel: *p<0.05 vs CT and ER; NS: p = 0.07 vs OxPAPC/ER. Middle panel: *p<0.05 vs CT, ER, and OxPAPC/ER. Bottom panel: *p<0.05 vs CT and ER; NS: p>0.05 vs FFA/ER.
Figure 3.
Representative Western blots (top panel) and bar graphs showing the effect of eritoran on LPS-induced phosphorylation of NF-κB p65 subunit (bottom left panel) and IκB-α (bottom right panel) (n = 5 per group).
Bottom left panel: *p<0.05 vs CT; NS: p>0.05 vs LPS/ER. Bottom right panel: **p<0.005 vs CT; NS: p>0.05 vs LPS/ER.
Table 1.
Baseline Characteristics of Study Participants.
Figure 4.
Representative images of the baseline brachial ultrasound of a participant with the aa genotype (top left picture), of a participant with the ag genotype (top right picture), and of the baseline and post-hyperemic ultrasound of a healthy control (bottom pictures).
The calculation of flow-mediated dilation (FMD) using the values collected in the healthy control is also reported.
Figure 5.
Flow-mediated dilation (top left panel) and plasma levels of IL-6 (top right panel), IL-8 (middle left panel), VCAM (middle right panel), ICAM (bottom left panel), and MCP-1 (bottom right panel) according to TLR4 genotype in study participants.
Values reported as mean±SD.