Table 1.
Demographic data of the patients with MS/CIS and SC
Figure 1.
Flowchart demonstrating exclusion and inclusion criteria for the study.
Patients were excluded if they had other neurologic disease, a medical disease, had been undergoing immune modulating treatment within the month preceding sampling, had paraclinical isolated syndromes, or if data were missing. Patients included in the study cohort were divided into five subgroups: relapsing-remitting MS (RRMS), primary progressive MS (PPMS), secondary progressive MS (SPMS), clinical isolated syndrome (CIS) and, symptomatic controls (SC) with either normal or unspecific MRI. Abbreviations: RRMS (relapsing-remitting MS), PPMS (primary-progressive MS), SPMS (secondary-progressive MS), CIS (clinically isolated syndrome), SC (symptomatic controls), CSF (cerebrospinal fluid), CI (confidence interval).
Figure 2.
Box plots of sCD163 concentrations, ratios, and indexes.
Four graphs (2a–2d) with levels of: sCD163 in CSF (2a); serum (2b); the sCD163 CSF/serum ratios (2c); and the sCD163 indexes (2d). The box plots displays the distribution of the parameters for each group, RRMS, PPMS; SPMS; CIS and SC. The line in the box indicating the median level, whiskers fences the upper and lower quartiles, and “o” labels the outliers. Abbreviations: RRMS (relapsing-remitting MS), PPMS (primary-progressive MS), CIS (clinically isolated syndrome), SC (symptomatic controls), CSF (cerebrospinal fluid), CI (confidence interval).
Table 2.
Median levels of sCD163 in serum and CSF samples as determined by ELISA.
Table 3.
Results from linear regression analyses of differences between patients with MS/CIS and SC.
Figure 3.
ROC curves generated for serum sCD163, CSF sCD163, sCD163 CSF/serum ratio, sCD163 Index, and IgG Index.
AUC, with 95% CI, is given for each parameter. The parameter results for patients with MS/CIS are combined as true positives and plotted against SC as true negatives. The diagonal dividing the ROC space represents the random event. Abbreviations: ROC (receiver operating characteristic), AUC (area under the curve), CIS (clinically isolated syndrome), SC (symptomatic controls), CSF (cerebrospinal fluid), CI (confidence interval).