Table 1.
Demographics of patients and controls.
Figure 1.
Different respiratory states in controls and at three time points over one week in patients with sepsis in permeabilised (A) and intact cells incubated in their own plasma (B). Controls n = 38, patients n, 1st time point = 38, 2nd time point = 31, 3rd time point = 27. Displayed as mean ± SD. * = p<0.05, ** = p<0.01, *** = p<0.001.
Figure 2.
Plasma analysed from septic patients at three different time points (within 48 h, day 3–4 and day 6–7 of ICU stay). Controls were set to 100% for each cytokine and septic plasma values are expressed as log (%) relative difference. Controls n = 12, patients n, 1st time point = 38, 2nd time point = 31, 3rd time point = 27, bars = median ± interquartile range. * = p<0.05, ** = p<0.01, *** = p<0.001 compared to controls.
Figure 3.
Influence of septic plasma on mitochondrial respiration.
Intact platelets incubated for 1(white) or septic patients on day 1–2 (light grey), day 3–4 (dark grey) or day 6–7 (black) post admission to ICU. Stimulated to maximal respiration with FCCP. Controls n = 19, patients day 1–2 n = 18, day 3–4 and day 6–7 n = 17. Displayed as mean ± SD. * = p<0.05.