Table 1.
Mankin's scoring for the cartilage degradation.
Figure 1.
The concentrates of platelets in PRP and whole blood.
(A): The smear of PRP and whole blood. Platelets and white blood cells were highly concentrated in PRP. (B): The platelets counting of PRP and whole blood. * denotes statistically different significance compared with whole blood (p<0.01).
Table 2.
Concentrations of GFs in peripheral blood and PRP.
Figure 2.
Histological assessment of cartilage restoring effects of the three groups.
The left two columns were H&E stained and the right two columns with Safranin-O. For each staining, the images of the right column are magnified from the left column. The capillary infiltration areas were indicated with black arrows. All scale bars represent 200 µm.
Figure 3.
Mankin's score of the three groups at 6 w and 12 w.
The score of the PRP group was lower than the other two groups at both time points. * denotes statistically significant difference compared with the control group(p<0.05). # denotes statistically significant difference compared with the HA group(p<0.05).
Figure 4.
(A).Assessment of subchondral bone restoration in PRP group. Bright yellow represents regenerated bone and blue for tissue with lower density, such as fibrous tissue. (B).Comparison of bone mineral density(BMD) and BV/TV between the three groups and normal bone tissue(positive). *denotes statistically significant difference compared with positive group(p<0.01) and PRP group(p<0.01); #denotes none statistically significant difference compared with the positive group(p>0.05).
Figure 5.
Comparison of the IL-1 concentrations in the three groups.
* denotes statistically significant difference compared with HA group or the control group(p<0.01); $ denotes statistically significant difference compared with the control group(p<0.05).