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Table 1.

Summary of Confounding Variables, by Category, Measured Prior to Index Prescription and by which Propensity Scores were Adjusted.

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Figure 1.

Patient record selection.

n = 10,338,432 research-quality patients in CPRD-COPD; n = 645,287 new users of ICS-containing or new users of LABD medications COPD: chronic obstructive pulmonary disease; HES: Hospital Episode Statistics; ICS: inhaled corticosteroid; LABD: long-acting bronchodilator.

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Table 2.

Demographics from the Baseline Period (Year Before Cohort Entry) and Patient History for the Final Analysis Cohort Before and After Propensity Score Balancing.

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Figure 2.

Pneumonia by different definitions among new users of ICS-containing and LABD medications (primary and sensitivity models).

Data are hazard ratios and 95% CI for ICS compared with LABD. The incidence rates of pneumonia events per 1,000 person years for each group are presented below the figure for the primary model only. ICS: inhaled corticosteroid; LABD: long-acting bronchodilator.

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Figure 3.

Pneumonia by different definitions and ICS daily dose in new users of ICS-containing medications.

Data are hazard ratios and 95% CI for ICS compared with LABD. CFC: chlorofluorocarbon; ICS: inhaled corticosteroid; LABD: long-acting bronchodilator.

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