Table 1.
Patient characteristics.
Figure 1.
Preoperative imaging, histology, absoption- and phase-contrast CT of case 1.
Preoperative ultrasonography (A) with typical benign imaging characteristics of the fibroadenoma (FA) (oval form, smooth margins, posterior enhancement); preoperative craniocaudal (B) and mediolateral oblique (C) mammography projections show the fibroadenoma (FA) partially hidden within the dense breast parenchyma (BP) (ACR IV). Representative histological slice (D) and corresponding absorption- (E) and phase-contrast CT (F) image. (G) and (H) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively: The peaks in (H) correspond to the different grey levels of formalin (fo), FA and surrounding breast parenchyma (BP). The “shoulder” of the histogram in (H) corresponds to adipose tissue. In (G), only two distinct peaks for adipose tissue and formalin, FA and breast parenchyma are seen. Window levels are marked with dashed red lines. The tumor boundaries are indicated by arrowheads; one sclerotic strand is indicated by long arrows. Adipose tissue is indicated by short arrows. The black sharp lines in the corners of (E) and (F) correspond to the walls of the plastic container. The ducts are artificially torn open in (D) due to cutting and staining procedures.
Figure 2.
Preoperative imaging, histology, absoption- and phase-contrast CT of case 2.
Preoperative mediolateral oblique mammogram (A) shows the fibroadenoma (FA) within a transparent breast (ACR II). Ultrasonography (B) of the FA. Representative histological slice (C) of the FA. Corresponding absorption- (D) and phase-contrast CT (E) slice. Arrowheads indicate septum with interspersed adipose tissue. Arrows indicate sclerotic strands. (F) and (G) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively. In (F), only two distinct peaks for adipose tissue and formalin (fo), water and FA are seen. In (G), there are four distinct peaks for adipose tissue, water, formalin and FA. Window levels are marked with dashed red lines.
Figure 3.
Preoperative imaging, histology, absoption- and phase-contrast CT of case 3.
Preoperative mediolateral oblique mammogram (A) shows the cystosarcoma phyllodes (CP) within a transparent breast (ACR II). Ultrasonography (B) of the CP. Representative histological slice (C) of the CP. Corresponding absorption- (D) and phase-contrast CT (E) slice. Rectangle in (C), (D) and (E) indicates the borders between adipose tissue (AT), CP and breast parenchyma (BP). (F) and (G) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively, with only two distinct peaks for adipose tissue and formalin (fo), water, CP and BP in (F) and different grey levels for adipose tissue, formalin & water, CP & BP in (G). Window levels are marked with dashed red lines. Arrowheads in (D) and (E) indicate plastic container surrounding the sample. Asterisk (*) indicates polymethylmethacrylate (PMMA) stick, X indicates plastic tube filled with water; both materials can be used for calibration in quantitative studies (not used here).
Figure 4.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 4.
Preoperative ultrasonography (A) shows the fibroadenoma (FA) as lobulated mass with smooth margins. Representative histological slice (B) and corresponding absorption- (C) and phase-contrast CT slice (D). (D) show strands of hypocellular sclerosis (long arrows) as well as torn-open ducts (arrowheads) filled with formalin. Adhering adipose tissue indicated by short arrow. Histograms of the whole 3D volume dataset of the absorption- (E) and phase-contrast (F) CT, respectively, show distinct peaks for adipose tissue, water, formalin (fo) and FA in (F) whereas in (E), the peaks for water, formalin and FA overlap. Window levels are marked with dashed red lines.
Figure 5.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 5.
Preoperative mediolateral-oblique (A) and craniocaudal (B) mammogram and ultrasonography (C) showing the fibroadenoma (FA). Representative histological slice (D) showing the FA, surrounded by adipose tissue (AT) and breast parenchyma (BP). Absorption- (E) and phase-contrast CT (F) slice; black rectangle showing zoomed view of a polygonal sclerotic frame (pink in (D), bright in (F) filled with basophilic branched ducts; one linear duct indicated by arrow in (D) and (F). (G) and (H) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively, with only two distinct peaks for adipose tissue and formalin (fo), water, fibroadenoma and breast tissue in (G) and different grey levels for adipose tissue, water, formalin and fibroadenoma & breast tissue in (H). Window levels are marked with dashed red lines. Arrowheads in (E) and (F) indicate plastic container surrounding the sample. Asterisk (*) indicates polymethylmethacrylate (PMMA) stick, X indicates plastic tube filled with water; both materials can be used for calibration in quantitative studies (not used here).
Figure 6.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 6.
Preoperative ultrasonography (A) of the fibroadenoma (FA). Representative histological slice (B) of the FA. Corresponding absorption- (C) and phase-contrast CT (D) slice. Long arrows indicate strands of fibrous tissue. Short arrows indicate adhering adipose tissue. (E) and (F) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively. In (E), only two distinct peaks for adipose tissue and formalin (fo), water and FA are seen. whereas in (F), the histogram reveals four distinct peaks for adipose tissue, water, formalin and fibroadenoma. Window levels are marked with dashed red lines. Arrowheads in (C) and (D) indicate plastic container surrounding the sample.
Figure 7.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 7.I.
Preoperative craniocaudal mammography (A) and ultrasonography (B) of the fibroadenoma (FA). Representative histological slice (C) of the FA. Corresponding absorption- (D) and phase-contrast CT (E) slice. Long arrows indicating ducts. Short arrows indicate adhering adipose tissue. (F) and (G) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively. In (F), only two distinct peaks for adipose tissue and water, formalin (fo) and FA are seen. In (G), there are four distinct peaks for adipose tissue, water, formalin and FA. Window levels are marked with dashed red lines. Arrowheads in (D) and (E) indicate plastic container surrounding the sample.
Figure 8.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 8.
Preoperative craniocaudal mammography (A) and ultrasonography (B) of the tumor (TU) containing a pseudoangiomatous stromal hyperplasia. Representative histological slice (C) of the tumor. Corresponding absorption- (D) and phase-contrast CT (E) slice. Long arrows indicating ducts. Short arrows indicate adhering adipose tissue. (F) and (G) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively. In (F), only two distinct peaks for adipose tissue and formalin, water and breast tissue are seen. In (G), there are four distinct peaks for adipose tissue, water, formalin and breast tissue. Window levels are marked with dashed red lines. Arrowheads in (D) and (E) indicate plastic container surrounding the sample.
Figure 9.
Preoperative imaging, histology, absorption- and phase-contrast CT of case 9.
Preoperative ultrasonography (A) of the tumor (TU). Representative histological slice (B) of the mastopathic area (MP with adhering adipose tissue (AT). Corresponding absorption- (C) and phase-contrast CT (D) slice. (E) and (F) show the histograms of the whole 3D volume dataset of the absorption- and phase-contrast CT, respectively. In (E), only two distinct peaks for adipose tissue and formalin (fo), water and breast tissue are seen. In (F), there are four distinct peaks for adipose tissue, water, formalin and breast tissue. Window levels are marked with dashed red lines. Arrowheads in (C) and (D) indicate plastic container surrounding the sample.
Table 2.
Setup specifications and scan parameters.