Figure 1.
Alkaloids isolated from stem bark of Zanthoxylum rhoifolium.
Figure 2.
Figure illustrating the structure-activity relationship for the antimicrobial activity of benzophenanthridine alkaloids.
Table 1.
Minimum amount required (in µg) for inhibition of microbial growth on TLC plates for extracts and isolated alkaloids of Z. rhoifolium.
Table 2.
Antimicrobial activity (MIC/MBC and MFC in µg/mL) for extracts and isolated alkaloids of Z. rhoifolium.
Figure 3.
Reaction by obtention of 2,3-dihydroxy chelerythrine derivative (14) from Chelerythrine (10).
Table 3.
Antimicrobial activity (MIC/MBC and MFC in µg/mL) for Chelerythrine (10) and 2,3-dihydroxy chelerythrine derivative (14).
Figure 4.
Chelerythrine (CHE) in vitro effect on human erythrocytes: (A) Erythrocytes count; (B) Hemolysis; (C) Lipoperoxidation evaluated by TBARS assay; (D) protein oxidation evaluated by Advanced Oxidative Protein Products (AOPP) assay.
CHE treatments were compared to control group by one-way analysis of variance followed by Dunnet post hoc test. * = p<0.05; ** = p<0.01; *** = p<0.001.