Table 1.
Demographic information and tumor classification for study subjects.
Figure 1.
Example of BOLD functional magnetic resonance imaging activation maps and BOLD signal time courses in the LPMC, RPMC and SMA during a motor task in a single patient with glioma and a healthy control subject.
BOLD, blood oxygen level dependent; LPMC, left primary motor cortex; RPMC, right primary motor cortex; SMA, supplementary motor area.
Figure 2.
Group differences in the functional connectivity of the motor network between patients with brain gliomas and healthy controls.
Error bars represent standard error of the mean. A blue asterisk indicates significant differences between groups (z = −3.215, P = 0.001, Mann-Whitney U test). LPMC, left primary motor cortex; RPMC, right primary motor cortex; SMA, supplementary motor area.
Figure 3.
The power spectral density (PSD).
A, B, and C show the group mean PSD in the LPMC, RPMC and SMA between healthy subjects (red traces) and patients with brain gliomas (blue traces). D, The localization of three key motor regions. In patients with brain gliomas, the PSDs in the LPMC, RPMC, and SMA are significantly lower than the PSDs of healthy controls (P<0.05). LPMC, left primary motor cortex; RPMC, right motor cortex; SMA, supplementary motor area.
Figure 4.
Bar graphs show the PSD in the three non-overlapping frequency bands for the three key regions of the motor network in healthy subjects and patients with brain gliomas.
The sub-divisions of the low-frequency band were: low, 0.01–0.02 Hz; middle, 0.02–0.06 Hz; and high, 0.06–0.1 Hz. Patients with brain tumors show significant PSD decreases in all bands in all three key motor cortical regions (LPMC, RPMC, and SMA) (*P<0.05; ** P<0.001). PSD, power spectral density; LPMC, left primary motor cortex; RPMC, right motor cortex; SMA, supplementary motor area.
Table 2.
Statistical comparisons of power spectral density in different brain regions between groups.