Table 1.
BNP concentration and left ventricular ejection fraction (LVEF) in patients grouped according to the major end points; hospitalization for congestive heart failure (CHF) and death.
Figure 1.
Received operating characteristic (ROC) curve for detection of CHF by BNP in patients treated with cardiotoxic chemotherapy.
Area under the curve is 0.77 (95% CI 0.65–0.90, p<0.001). The arrows indicate selected cut-off concentrations of BNP. BNP concentration of 100 pg/ml correspond to a sensitivity 38% of and a specificity of 92% and BNP concentration of 30 pg/ml corresponds to a sensitivity 81% of and a specificity of 62%.
Figure 2.
Received operating characteristic (ROC) curve for detection of CHF by LVEF in patients treated with cardiotoxic chemotherapy.
Area under the curve is 0.67 (CI 0.53–0.81, p = 0.008). The arrows indicate selected cut-off concentrations for LVEF. A LVEF of 50% correspond to a sensitivity of 48% and a specificity of 91%. The diagnostic performance of LVEF at 45% and 55% showed a sensitivity of 38% and 45% and specificity of 97% and 78%, respectively.
Table 2.
Prognostic performances of BNP and LVEF in predicting hospitalization for congestive heart failure during follow up.
Table 3.
Prognostic performances of BNP and LVEF in predicting death during follow up.
Figure 3.
Kaplan-Meier analysis for the probability of CHF hospitalization-free survival according to BNP levels below (black, solid) or above the cut-off level of 100 pg/ml (black, dashed).
Figure 4.
Kaplan-Meier analysis for the probability of CHF hospitalization-free survival according to LVEF above (black, solid) or below 50% (black, solid).
Figure 5.
Kaplan-Meier analysis for the probability of over-all survival according to BNP levels below (black, solid) or above the cut-off level of 100 pg/ml (black, dashed).
Figure 6.
Kaplan-Meier analysis for the probability of over-all survival according to LVEF above (black, solid) or below 50% (black, dashed).
Table 4.
Univariate Cox regression analysis for predicting hospitalization for congestive heart failure in relation to selected cut-off values of BNP concentration and LVEF.
Table 5.
Univariate Cox regression analysis for predicting overall death in relation to selected cut-off values of BNP concentration and LVEF.