Figure 1.
Flowchart of patient selection.
Table 1.
Demographic, clinical, and laboratorial characteristics of patients with dengue fever (DF), warning signs, and severe dengue (SD).
Figure 2.
A 16-year-old girl with a confirmed diagnosis of dengue and reduced exercise tolerance and breathlessness.
CT images show large bilateral pleural effusion (a, mediastinal window) and no abnormality of the lung parenchyma other than compressive atelectasis (b, lung window).
Figure 3.
A 78-year-old man with a confirmed diagnosis of dengue.
CT images (a, b) show moderate and diffuse ground-glass opacities with no specific distribution in the lungs.
Figure 4.
A 30-year-old woman with a confirmed diagnosis of dengue and respiratory failure requiring non-invasive ventilation.
CT image acquired 6 days after the onset of clinical symptoms (a) shows interlobular septal thickening, mild ill-defined ground-glass opacities, and peribronchovascular interstitial thickening. Bilateral pleural effusion is also present. Complete resolution of the parenchymal abnormalities was observed on a CT images (b) obtained 7 days later.
Figure 5.
Histopathological analysis of lung sections from fatal dengue cases (a, b, c), stained with hematoxylin and eosin, showed pulmonary alterations, including alveolar septal thickening, hyaline membrane formation (HM), hemorrhage (He), edema (E), and the presence of type II pneumocytes (PcyII).