Table 1.
Socio-demographic and clinical data of 221 HIV seropositive individuals from Cape Verde distributed according to the type of virus.
Figure 1.
Phylogenetic tree analysis of the pol region of HIV-1 “pure subtype” samples from Cape Verde.
The phylogenetic inferences were performed by the Neighbor-Joining algorithm under the Kimura-2 parameter nucleotide substitution model using the MEGA v5.0 package. The scale represents the number of substitutions per site. Cape Verde and reference sequences are represented, respectively as black and white circles.
Figure 2.
Phylogenetic tree analysis of the pol region of HIV-1 CRF and major URF samples from Cape Verde.
The phylogenetic inferences were performed by the Neighbor-Joining algorithm under the Kimura-2 parameter nucleotide substitution model using the MEGA v5.0 package. The scale represents the number of substitutions per site. Cape Verde and reference sequences are represented, respectively as black and white circles. Bootscan analyses of HIV-1 major URF samples are displayed. Recombinant profiles were inferred using a sliding window of 200 bp, steps of 20 bp and the Kimura-2 parameters model using SimPlot 3.5.1 software. Reference samples corresponding to the major HIV-1 subtypes are indicated by different colors.
Figure 3.
Phylogenetic tree and bootscan analyses of the pol region of HIV-1 URF samples from Cape Verde.
(A) The phylogenetic inferences were performed by the Neighbor-Joining algorithm under the Kimura-2 parameter nucleotide substitution model using the MEGA v5.0 package. The scale represents the number of substitutions per site. Cape Verde and reference sequences are represented respectively as colored and white circles. (B) Recombinant profiles were inferred using a sliding window of 200 bp, steps of 20 bp and the Kimura-2 parameters model using SimPlot 3.5.1 software. Reference samples corresponding to the major HIV-1 subtypes are indicated by different colors. Partial NJ phylogenetic trees using K-2p model were performed for bootscan fragments under 70% and were represented as I - 150 bp and II and III - 300 bp.
Figure 4.
Phylogenetic tree analysis of the Cape Verde HIV-2 pol region samples (black circles and squares).
The phylogenetic inferences were performed by the Neighbor-Joining algorithm under the Kimura-2 parameter nucleotide substitution model using the MEGA v5.0 package. Reference sequences from HIV-2 Group A and B are included and represented as white circles. The scale represents the number of substitutions per site.
Table 2.
Socio-demographic and clinical data of HIV-1 seropositive individuals from Cape Verde distributed according to the main viral genetic characterization in the pol region.
Table 3.
Prevalence of Drug Resistance Mutations in HIV-1 ART naïve individuals and HIV-1 and HIV-2 patients under ART.