Table 1.
Baseline characteristics of the CARLA collective – differentiated according to sex and presence of prolonged QT time.
Figure 1.
Association of prolonged QTc time and inflammation parameters.
Odds ratios (OR) with 95% confidence interval. Unadjusted regression models of inflammation parameter. OR refers to a 1,000 pg/mL increase in sTNF-R1, a 10 pg/mL increase in IL-6, and a 10 mg/L increase in hsCRP.
Figure 2.
Association of prolonged QTc time and inflammation parameters.
Odds ratios (OR) with 95% confidence interval. Models were adjusted for age, anti-arrhythmic (ATC code: C01B) and anti-phlogistic medication (ATC code: A07), current smoking status, high density lipoprotein (HDL), cholesterol, glucose blood level, alcohol intake, body mass index, thyroid stimulating hormone (TSH), systolic blood pressure and potentially QT prolonging drugs (see www.qtdrugs.org). OR refers to a 1,000 pg/mL increase in sTNF-R1, a 10 pg/mL increase in IL-6, and a 10 mg/L increase in hsCRP.
Figure 3.
Scatter plot of corrected QT time dependent on sTNF-R1.
x-axis: Soluble tumor necrosis factor type 1 (sTNF-R1) in pg/mL; y-axis: heart rate corrected QT time (QTc) in ms.
Table 2.
Linear regression of QTc, QT time and heart rate (HR) on sTNF-R1 in men and women (estimates with 95% confidence interval).