Table 1.
Subjects.
Figure 1.
Sample qMRI data maps from a 45-years-old female MRIpos MS patient.
a) R1 map, b) R2 map, c) PD map, d) synthetic T2-weighted image is shown for reference. Several partially liquefied lesions are visible (red arrows in d).
Figure 2.
Typical VOI placement in MS patients.
Figure 3.
Typical ROI placement in MS patients and healthy controls.
a) DAWM in MRIneg, b) NAWM in MRIneg, c) DAWM in MRIpos, d) NAWM in MRIpos, e) WM lesion in MRIpos, f) NWM in a healthy control. MRIneg subject was a 43 years old female, MRIpos subject was a 66 years old female and healthy subject was a 42 years old female.
Figure 4.
Tissue clusters and in vivo data, in the 3D feature space formed by R1-R2-PD, projected on a,d) R1-R2, b,e) R1-PD and c,f) R2-PD planes.
Figures a-c shows NAWM, DAWM and NAWM, figures d-f shows NWM and WM lesions. Cluster ellipses indicates the calculated covariance's of each tissue type separately, red ellipses correspond to the MRIneg group, blue ellipses correspond to the MRIpos group, and the dashed black ellipses correspond to the NWM tissue cluster in healthy controls. The indicated ellipses enclose 95% of the in vivo data.
Table 2.
Descriptive statistics (mean ± SD) and group comparisons for tissue types, in all groups.
Table 3.
Pearson correlations between qMRI properties and clinical parameters.
Table 4.
Correlations between qMRI properties of NAWM and NWM, in all groups, and qMRS metabolite concentrations.
Table 5.
Correlations between mean qMRI parameter values within the larger qMRS VOIs of NAWM and NWM and qMRS metabolite concentrations measured in the same VOIs.
Table 6.
Association between qMRI measurements and brain parenchyma fraction (BPF).
Table 7.
Association between qMRI measurements and MS Severity Score (MSSS).