Table 1.
Demographic and Clinical Characteristics of the HTLV-1 Patients (n = 90).
Figure 1.
Phylogenetic tree of HTLV-1 sub-subtypes based on Bayesian Inference analysis of the complete coding region sequences (7593 bp, nucleotide 804–8397 according to position in B1033-2009 “GenBank accession no. AB513134”) of 76 participant samples.
Colored (blue, sub-subtype aA; red, sub-subtype aB) and black branches represent patient samples and reference sequences from all verified sub-subtypes, respectively. Sequences displayed simultaneous base substitutions over the complete coding region (see Table 2) and formed a monophyletic cluster are indicated by yellow box. For clarity, the tree was midpoint rooted. Values at the nodes represent Bayesian probabilities.
Table 2.
Alignment of nucleotide variations detected simultaneously in the HTLV-1 proviral complete coding region from 27 participants.
Table 3.
Comparison of the nucleotides of the transcontinental (A) and Japanese (B) sub-subtypes of the cosmopolitan genotype*.
Figure 2.
Phylogenetic tree of HTLV-1 sub-subtypes based on Bayesian Inference analysis from the long terminal repeat (LTR, 664 bp) of 88 participant samples and 279 HTLV-1 LTR sequences from the database representing 5 of the HTLV-1 subtypes.
The representatives of the 5 references are color-coded. Branches with posterior probabilities ≥0.70 are displayed with blank square.
Figure 3.
Bayesian analysis of 297 long terminal repeat (LTR) sequences from various global locations (colored branch), including previously published Brazilian and other South American sequences from neighboring countries.
The tree also contains 88 sequences from the current study. Branches with posterior probabilities ≥0.70 are displayed (white dots).