Table 1.
Baseline characteristics for total population and stratified by type of endpoint.
Figure 1.
Course of symptoms during pre-dialysis care.
The course of the total number of symptoms is presented for the total population (A) and stratified by the type of endpoint reached (combined poor health outcome; dialysis/transplantation/death, or end of follow-up/other endpoint, B). The black and grey dots indicate the mean and the error bars indicate the standard error of the mean (SEM). The time in months before reaching an endpoint is presented on the x-axis (−12 means that the measurement was 7–12 months before reaching an endpoint, −18 means 13–18 months etc). On the y-axis, the mean (SEM) total number of symptoms is presented, which can range from 0 to 12.
Table 2.
Comparison of the presence of symptoms and HRQOL at the start of pre-dialysis care and the moment of reaching an endpoint.
Figure 2.
Course of HRQOL during pre-dialysis care.
The course of the physical and mental summary score are presented for the total population (A) and stratified by the type of endpoint reached (combined poor health outcome; dialysis/transplantation/death, or end of follow-up/other endpoint, B). The black and grey dots indicate the mean and the error bars indicate the standard error of the mean (SEM). The time in months before reaching an endpoint is presented on the x-axis (−12 means that the measurement was 7–12 months before the moment of reaching an endpoint, −18 means 13–18 months etc). On the y-axis, the mean (SEM) score from the SF-36 questionnaire is presented (separately for the physical and mental summary measure), which can range from 0 to 100.
Figure 3.
Course of eGFR and CrCl during pre-dialysis care.
The course of eGFR and CrCl are presented for the total population (A) and stratified by the type of endpoint reached (combined poor health outcome; dialysis/transplantation/death, or end of follow-up/other endpoint, B). The black and grey dots indicate the mean and the error bars indicate the standard error of the mean (SEM). The time in months before reaching an endpoint is presented on the x-axis (−12 means that the measurement was 7–12 months before the moment of reaching an endpoint, −18 means 13–18 months etc). On the left y-axis, the mean (SEM) eGFR (ml/min/1.73 m2) is presented, and on the right y-axis the mean (SEM) CrCl (ml/min/1.73 m2).
Table 3.
Association of symptoms and a low HRQOL with the risk of reaching the combined poor health outcome within the subsequent 6 months based on separate time-dependent Cox proportional hazard models.
Table 4.
Association of symptoms and a low HRQOL with the risk of starting dialysis within the subsequent 6 months based on separate time-dependent Cox proportional hazard models.