Table 1.
Study cohorts.
Figure 1.
Severe fever with thrombocytopenia syndrome virus (SFTSV) RNA loads in blood.
(A) The kinetics of viral RNA levels of individual patients between 5–15 days after onset of fever during hospitalization. Each curve represents one patient. The red curves indicate the deceased patients while the black curves represent the survivors. (B) The viral loads of the deceased patients and survivors as indicated on Day 9 after onset of fever. Each dot represents one patient. Statistical significance (p<0.0001) of viral loads between deceased patients and survivors is indicated.
Figure 2.
The kinetics of platelet (PLT) (A) and white blood cell (WBC) (B) counts, serum alanine transaminase (ALT) (C), aspartate transaminase (AST) (D), lactic dehydrogenase (LDH) (E), and creatine kinase (CK) (F) in SFTSV-infected patients.
The red and black curves represent the deceased patients or the survivors, respectively, as the mean cell counts with standard error (A and B) or mean enzyme units/liter of blood with standard error (C–F) at each time point during hospitalization from Day 5 to Day 15 after onset of fever. The grey area in each graph indicates the normal range of related lab tests. Statistical significance (p<0.05) was indicated for each enzyme between deceased patients and survivors on Day 9 from onset of fever (C–F).
Table 2.
Critical parameters that may be associated the severity of SFTS.
Figure 3.
Dynamic changes in T cell subsets in SFTSV-infected patients.
The red and black curves represent the deceased patient group and the survivors, respectively. The values are presented as mean percentages with standard error of each T cell subset at each time point during hospitalization from Day 5 to Day15 days from onset of fever. The green dashed line in each graph indicates the mean percentage in the normal control group. Statistical significance (p<0.05) was indicated in graphs A and C for the difference of individual T cell subsets between deceased patients and survivors on Day 9 from onset of fever, and in graphs B, D, E and F for the difference of individual T cell subsets between survivors and the normal control group on Day 13 from onset of fever.
Figure 4.
Serum cytokine profiles in SFTSV-infected patients on Day 7 after onset of fever.
(A) Cytokines (IL-2, IL-4, TNF-α, and IL-17) that were not significantly different between SFTSV-infected patients and normal control group. (B) Cytokines (IL-6, IL-10, and IFN-γ) that were significantly different between SFTSV-infected patients and normal healthy donors. For each cytokine, * and ** indicate the statistical significance at p<0.05 and p<0.001, respectively.
Figure 5.
The kinetics of serum IL-6 (A), IL-10 (B), and IFN-γ (C) in SFTSV-infected patients during hospitalization between Day 5 and Day 15 from onset of fever.
In all three graphs, the red and black curves represent the deceased patient group and the survivors, respectively. The values were presented as mean cytokine concentrations with standard errors at each time point. The green dashed line in each graph indicates mean cytokine concentrations in the normal control group. Statistical significance (p<0.05) was indicated between deceased patients and survivors on Day 9 from onset of fever.