Figure 1.
Pie chart showing the distribution by compound type.
Figure 2.
Pair-wise distribution of Lipinski parameters for the p-ANAPL library; (A) log P against MW, (B) HBA against MW, (C) HBD against MW and (D) NRB against MW.
Figure 3.
Distribution of Lipinski parameters for the p-ANAPL library; (A) Bar chart showing the number of Lipinski violations, (B) Bar chart showing the MW parameter, (C) Plot of the lipophilicity parameter, (D) Plot of the HBA parameter, (E) Plot of the HBD parameter, and (F) Plot of the NRB parameter.
Figure 4.
Chemical structures of selected bioactive natural products from the p-ANAPL library (1 to 7).
Figure 5.
Chemical structures of natural products from the p-ANAPL library with log P > 8 units.
Table 1.
Summary of physico-chemical properties (often used to predict ‘drug-likeness’) of the compounds within the p-ANAPL library.
Figure 6.
Chemical structures of selected bioactive natural products from the p-ANAPL library (14 to 36).