Table 1.
Information of EV71 and species A coxsackieviruses isolated from aseptic meningitis patients in Shandong, China in 2006–2012.
Table 2.
Isolation and homologous comparison of human enteroviruses from Shandong meningitis patients.
Figure 1.
Monthly distribution of different serotypes isolated from aseptic meningitis cases in Shandong, 2006–2012.
E, echovirus; CV, coxsackievirus; EV, enterovirus.
Figure 2.
Phylogenetic tree based on E30 VP1 sequences of Shandong isolates and global strains.
Chinese strains are grouped into two clusters. Circles indicate strains obtained in this study, triangles indicate reference strains from previously reported aseptic meningitis outbreaks in the provinces of Zhejiang, Jiangsu, Fujian and Shandong of mainland China.
Figure 3.
Phylogenetic tree based on EV71 VP1 sequences of Shandong isolates and reference strains of genogroup C.
EV71 Strains from Shandong meningitis patients belong to C4a subgenogroup. Circles indicate strains obtained in this study, triangles indicate Shandong AFP strains, and squares indicate Shandong HFMD reference strains in 2007 to 2010.
Figure 4.
Phylogenetic tree based on CVB1 VP1 sequences of Shandong isolates and global strains.
Circles indicate strains obtained in this study, triangles indicate Shandong AFP strains.
Figure 5.
Phylogenetic tree based on VP1 sequences of CVA4, CVA10 and CVA16 among Shandong isolates and reference strains.
Circles indicate strains obtained in this study, triangles indicate Shandong AFP strains, and squares indicate Shandong HFMD strains.