Figure 1.
Flow chart of the patients.
Table 1.
Baseline characteristics of the overall population.
Table 2.
Characteristics of patients with ACLF included in the OPLS analysis.
Figure 2.
OPLS score plot and spectra of the CLF and ACLF patients.
A: Score plot separating CLF (blue) and ACLF (red) patients. B and C: Representative spectra showing the metabolic differences between patients with CLF or ACLF. Legends: a: -CH3 of fatty acid; b; -CH2 of fatty acid; c: glucose (C) and hydroxy-ethyl starch (B); d: fumaric acid; 1: cholesterol; 2: hydroxybutyrate; 3: lactate; 4: acetoacetate; 5: pyruvate; 6: glutamine; 7: creatinine; 8 & 9: aromatic amino acids (phenylalanine and tyrosine).
Figure 3.
OPLS line plot showing the discriminant metabolites between patients with CLF or ACLF.
Variations of metabolites are represented using a line plot between 0–9 ppm. Positive signals correspond to metabolites present at increased concentrations in the ACLF group. Conversely, negative signals correspond to metabolites present at increased concentrations in CLF group. The buckets are labeled according to metabolite assignment, as presented in Table 3.
Table 3.
Discriminant metabolites observed by 1H-NMR spectroscopy.