Figure 1.
Representative scout view of the distal radius scanned with high resolution peripheral quantitative computed tomography.
The reference line is marked at the most proximal point of the inner aspect of the growth plate (marked with x). The region of interest (ROI) spanning 9.02 mm starts from 5 mm proximal to the reference line. 110 CT slices with a nominal resolution (voxel size) of 82 µm were obtained.
Figure 2.
Three-dimensional HR-pQCT image of the distal radius with crosscut showing the trabecular bone.
Figure 3.
Illustrations of A) bone morphometry parameters and B) trabecular separation and thickness.
Figure 4.
Correlation between serum total leptin and soluble leptin receptor (sOB-R) levels in AIS and controls.
Controls showed a significant negative correlation between serum total leptin and sOB-R (r = −0.250, p = 0.020), while AIS showed no correlation (r = 0.089, p = 0.394).
Table 1.
Anthropometrics, serum total leptin and sOB-R levels in controls and AIS girls.
Table 2.
Comparison of bone quality parameters between controls and AIS.
Table 3.
Correlations between cortical bone parameters, serum total leptin and sOB-R levels with and without age and BMI adjustment.
Figure 5.
Correlations of various HR-pQCT parameters with serum total leptin in AIS and controls.
Correlation analysis showed there was statistically significant correlation between serum total leptin and the following HR-pQCT parameters only in AIS: A) Trabecular volumetric bone mineral density (vBMD), B)Trabecular Area, C) Trabecular bone volume to tissue volume ratio (BV/TV), and D) Trabecular Thickness. The difference in correlations could be observed by crossing of the best fit lines.
Table 4.
Correlations between trabecular bone parameters, serum total leptin, and sOB-R levels with and without age and BMI adjustment.