Figure 1.
Study flow chart.
Table 1.
Brain injury on conventional MR imaging.
Figure 2.
TBSS analysis of whole-brain white matter FA according to conventional MR imaging abnormalities.
In each case FA is compared between the infants classified abnormal (by the criterion given), and the other infants in the cohort. Red-yellow pixels denote regions of white matter where FA values are different between groups with p<0.05–p<0.01, green pixels denote regions where p≥0.05.
Figure 3.
Whole-brain white matter FA according to perinatal clinical assessment.
p value maps are displayed as described in Figure 2. Neuro = neurological; Ther. hypotherm. = therapeutic hypothermia.
Figure 4.
Whole-brain white matter FA according to outcome assessment aged 3½ years.
p value maps are displayed as described in Figure 2, only using those with 3½ year outcome data for group-wise comparisons. Low Bayley III = infants with scores below predefined cut-offs for Bayley III (<82 for composite motor score, <85 for composite cognitive score); Slow head growth = isolated slow head growth (fall in head circumference centile from birth to follow-up of >2 standard deviations), with otherwise normal neurological examination and Bayley III scores.
Table 2.
Characteristics of children with adverse early childhood outcomes.
Table 3.
Early childhood outcomes of infants according to Sarnat neonatal encephalopathy staging.