Figure 1.
Different Examples of Cryobiopsy Showing UIP pattern.
A) A low-magnification image showing dense scarring obliterating the alveolar architecture and abruptly alternating with relatively normal lung (patchy fibrosis). Some fibroblastic foci are visible even at this magnification for their pale-gray color. B) Fibroblastic focus better visualized at higher magnification. C) An area of honeycombing.
Figure 2.
Lower lobe transbronchial cryobiopsy. A temporally homogeneous alveolar septal fibrosis is evident.
Table 1.
Prevalence and risk factors for Pneumothorax.
Figure 3.
Artifactual acute lung injury probably related to tissue damage from cold consisting in edema, intra-alveolar fibrin and blood. The lesion is seen in the lower left corner, consisting in an area of patchy fibrosis with some chronic inflammation and a fibroblastic focus (UIP with high confidence).
Figure 4.
Description of Pathologic Interpretations.
Abbreviations: EOS-PMN, Eosinophilic Pneumonia; FB, Follicular Bronchiolitis; HP, Hypersensitivity Pneumonitis; OP, Organizing pneumonia; DAD, diffuse alveolar damage.
Table 2.
Detailed Analysis of Pathologists' Interpretations of UIP cases.
Table 3.
Discordant Pathologic Blind Interpretations.
Figure 5.
Correlations between Pathologic Interpretations of UIP cases and Final Diagnosis.
Report of pathologic interpretations and final diagnosis of 47 cases with UIP histologic features on cryobiopsy. TBLC column shows pathologic interpretations. HRCT column report radiologic characteristics of cases based on high resolution tomography findings. Last column summarises the final diagnosis achieved according to current ATS/ERS criteria.
Table 4.
Patients characteristics (Nr total = 69 pts).