Figure 1.
Schematic illustration of ASDCD.
Antifungal drug combinations were collected from PubMed, Google Scholar and Web of Knowledge. Information about chemical structure, drug-target interactions, and target-related pathways was primarily collected from KEGG, DrugBank and SuperTarget.
Figure 2.
Screenshot of ASDCD web interface is shown.
The number of individual drugs, drug target interactions, and synergistic drug combination, relevant history and the significance of synergistic drug combination, some basic information about ASDCD and an easy-to-use search tool are provided.
Figure 3.
ASDCD is compared with another drug combination database DCDB.
A) the comparison between ASDCD and DCDB in the term of the number of drugs in the database; B) the comparison in the term of the number of antifungal drugs; C) the comparison in the term of the number of drug combinations; D) the comparison in the term of the number of antifungal drug combinations. From above comparison, it can be easily observed that few antifungal drugs and drug combinations were collected in DCDB and ASDCD has provided much more drugs and drug combinations for the treatment of fungal infection.
Figure 4.
Fluconazole synergistic combination network includes fluconazole and other drugs yielding synergistic effect with fluconazole as nodes and the synergistic interactions between all the drugs in the network as edges.
In ASDCD, fluconazole obtains synergistic effect with as many as 42 drugs for antifungal treatment.