Figure 1.
Scatter plot showing sensitivity (Y) and specificity (X) of each of 720 variational Bayesian independent component analysis mixture (VIM) models created from FDT Matrix threshold sensitivities (52 inputs, plus age).
Results for the two best models (defined subjectively with a goal of 0.90 specificity and a maximum sensitivity) are shown.
Figure 2.
Plot of axis contribution of variational Bayesian independent component analysis mixture (VIM) (Y) versus number of axes (X).
Axes beyond the knee point were removed, leaving 2 axes each for Clusters 1 and 2 and 5 axes for Cluster 3. The best VIM model was retrained 500 times, constrained to the reduced number of axes.
Table 1.
Number of normal and abnormal FDT fields assigned to each VIM-identified cluster. Overall specificity was 0.931 and sensitivity was 0.828.
Figure 3.
Color-coded displays simulating total deviation plots along with age at −2 and +2 standard deviations of each axis from the centroid of Cluster N, that was composed primarily of normal FDT fields.
Axis 1 and Axis 2 appear normal or near normal. Numerical values shown are simulated total deviation values at each corresponding test point.
Figure 4.
Color-coded displays simulating total deviation plots along with age at −2 and +2 standard deviations of each axis from the centroid of the normal Cluster N, that was composed primarily of abnormal FDT fields.
Axis 1 appears to represent primarily moderate superior hemifield defects and Axis 2 appears to represent primarily moderate inferior hemifield defects (i.e., both are altitudinal defects), both showing less severe, diffuse loss in the opposing hemifield.
Figure 5.
Color-coded displays simulating total deviation plots along with age at −2 and +2 standard deviations of each axis from the centroid of normal Cluster N, that was composed entirely of abnormal FDT fields.
Axis 1 appears to represent diffuse moderate visual field loss. Axis 2 and Axis 3 appear to represent more severe superior nasal and inferior nasal defects, respectively. Axis 4 appears to represent combined superior and inferior nasal step defects, and Axis5 appears to represent a diffuse pattern of loss, primarily localized superiorly.