Table 1.
Chromosomal deletions and diseases.
Figure 1.
PGS charts of human blastocyst biopsies from Agilent oligo and Illumina BAC DNA array platforms.
Charts in left column are from Agilent and charts in right column are from Illumina BAC platforms. A and A': 46 XX; B and B': 46 XY; C and C': 47 XY, +14; D and D': 45 XY, −4, +15, -19. Arrows indicate chromosomal errors. Data matched between two array platforms.
Figure 2.
PGS charts of human blastocyst biopsies from Agilent and NimbleGen oligo DNA array platforms.
Charts in A and D are from Agilent and charts in B, C, E and F are from NimbleGen platforms. A, B and C: 46 XY; D, E and F: 45 XX, -15. Arrow indicates chromosomal error. Data matched between two array platforms.
Table 2.
Validation of chromosomes with three array platforms in human embryo samples.
Table 3.
Detailed analysis of microdeletions in the examined samples with Agilent DNA microarray.
Figure 3.
PGS chart and chromosomal view of a human blastocyst biopsy analyzed with Agilent array platform.
The PGS chart shows two chromosomal deletions (arrow) in chromosomes 5 and 12. The middle and bottom charts show the chromosomal views in both chromosomes, with deletion locations and sizes.
Figure 4.
PGS chart, chromosomal view, gene view and gene list of a human blastocyst biopsy analyzed with Agilent array platform.
The PGS chart (A) shows one chromosomal deletion (arrow) in chromosome 13. Chromosomal view chart (B) shows the deletion location (13q21–13q33). Gene view chart (C) shows the location of genes (58,205,958–114,797,160) and D shows the list of lost genes in the deleted region. Genes marked with red are those related with phenotypes.