Figure 1.
Location of seed regions for functional connectivity analysis
Right middle frontal gyrus: x = 44, y = 48, z = 7, radius of 6 mm. Right ventral striatal seed: x = 5, y = 6, z = -12, radius of 4 mm.
Figure 2.
Functional connectivity of right middle frontal seed
Patterns of significantly positive (red spectrum) and negative (blue spectrum) correlations with the right middle frontal gyrus (seed depicted in green) within all subjects and within the groups. Group comparison for significant correlations: PG patients < controls and PG patients > controls (violet spectrum). All maps are thresholded at a z-score > |2.3| (cluster-wise corrected using Gaussian random field theory and Bonferroni corrected for the number of seeds). Ncontrols = 19, NPGpatients = 19.
Figure 3.
Group differences in functional connectivity of the seeds
Plots show z-values for the significant clusters of difference (encircled in yellow). Number of subjects for right middle frontal gyrus seed region A): Ncontrols = 19, NPGpatients = 19, and for right ventral striatal seed region B): Ncontrols = 18, NPGpatients = 14.
Figure 4.
Functional connectivity of right ventral striatal seed
Patterns of significantly positive (red spectrum) and negative (blue spectrum) correlations with the right ventral striatum (seed depicted in green) within all subjects and within the groups. Group comparison for significant correlations: PG patients > controls (violet spectrum). Please note that the contrast controls > PG patients was not significant. All maps are thresholded at a z-score > |2.3| (cluster-wise corrected using Gaussian random field theory and Bonferroni corrected for the number of seeds). Ncontrols = 18, NPGpatients = 14.
Figure 5.
Significant positive correlations for connectivity patterns
Scatter plots show significant correlations between the mean z-values of the thresholded clusters of the group contrasts PG patients > controls and smoking habits (number of cigarettes per day [cig/d]), the nonplanning BIS subscale and the VAS for craving. Number of PG patients for right middle frontal gyrus seed region A): NPGpatients = 19, and for right ventral striatal seed region B): NPGpatients= 14.