Figure 1.
3D MRSI voxel localization in SN region for rostral slice.
Figure 2.
LCModel fitting results of the averaged spectrum from the rostral SN region in the control group with standard basis data set (A) and optimized basis data set (B).
Shown are the in-vivo spectra, the fitted spectra with baseline, and the residuals. A) Incomplete spectrum fit (mainly in the region between 2.2 and 2.8 ppm) with clear residuals and humpy baseline, B) improved spectrum fit with closely reproduced in-vivo spectrum and residuals at the noise level.
Table 1.
Individual concentrations [arbitrary units] of the three main metabolites NAA, choline, and creatine in PD patients and age-matched controls.
Table 2.
Metabolite concentrations [arbitrary units], estimated using the averaged spectra of PD patients and age-matched controls.
Figure 3.
Averaged spectra from the rostral (A) and caudal (B) SN regions of PD patients (red) and controls (green).
Beside significant differences in the signal intensities of the three main metabolites NAA, creatine, and choline between both groups, there are clear differences in the range from 2.1 to 2.9