Table 1.
Baseline demographic characteristics.
Figure 1.
Analysis of cortical thickness in comparing responders versus non-responders.
(A) Difference maps of cortical thickness between two groups. The color scale bar shows the difference in mean cortical thickness between the two groups, with blue and red indicating less and greater cortical thickness in non-responders, respectively. (B) Corrected t-statistical maps of cortical thickness. The non-responders had significantly less cortical thickness in the left orbital gyrus and right middle temporal gyrus compared with the responders (RFT-corrected P<0.05).
Figure 2.
TBSS analysis of fractional anisotropy (FA) in comparison of responder and non-responder groups.
Higher FA values of the non-responders compared with the responders were found in the bilateral frontal, corpus callosal (genu), and right parietotemporal WM (FWE-corrected P<0.05).
Figure 3.
A schematic illustration of the neuroanatomy in the pathophysiology of essential tremor (ET).
(A) The locus coeruleus (LC) and its related structure, a major cortical glutamatergic afferent from orbitofrontal cortex (OFC) [a], may play a role in the pathogenesis of ET through the coerulo-cerebellar pathway [b]. (B) The cerebello–thalamo–cortical loop [c] is also an important pathway implicated in ET. These two distinct structures are consistent with heterogeneous neuropathologies (Changes in the brainstem and cerebellum, respectively) demonstrated in previous postmortem studies. Beta blockers seem to act centrally via Renshaw cells [d], and the LC is a strong candidate for mediating the beta-adrenergic effects to this pathway.