Figure 1.
Raw phenotypic data profiles of three representative pigs experimentally infected with PRRSV.
The viremia profile categories are: undetectable within 42 dpi (black dotted line), mono-phasic experimental persistence up to 42 dpi (grey line ), and bi-phasic rebound (black line).
Figure 2.
Wood's and Extended Wood's model fits to viremia data of two representative pigs classified as non-rebounder (top graphs) and rebounder (bottom graphs).
Light-grey regions correspond to 95% posterior predictive intervals (PPI); dark-grey regions correspond to 50% PPIs. The actual data are shown as green dots and the green solid lines give the best-fit solutions for the Wood's model (A,C ) and Extended Wood's model (B, D), respectively.
Table 1.
Summary of the statistical classifications of the viremia profiles from the PRRSV challenge experiment
Figure 3.
The Wood's model residuals (3A) and the Extended Wood's model residuals (3B).
The red line shows the residual mean and the blue lines delimit two standard deviations from the mean.
Figure 4.
The Wood's(4A) and Extended Wood's(4B) model mean predictions and data-prediction correlations.
The black lines outline the mean model predictions, and the dashed grey lines delimit the 95% prediction confidence intervals. The dotted black lines joined with crosses show the Pearson product-moment correlations between observed data and predicted values.
Table 2.
The Wood's and Extended Wood's model parameter's Pearson product-moment correlations.
Figure 5.
Woods parameters and mean model predictions for the 3 profile classes.
Figure 5A-C. Pair-wise scatter plots and clustering of primary phase Wood's model parameters for the 3 profile classes: cleared (blue circles), persistent (pink diamonds) and rebound (black crosses). Figure 5D. Mean Woods model predictions with the 95% Confidence Intervals (dashed lines) based on the truncated data from 0–21 dpi for individuals previously classified as rebound (black), persistent (pink) and cleared(blue), respectively.
Table 3.
Viremia profile class and their Least Square Means (LSM) from the truncated data.
Table 4.
Neutralising antibody (nAb) data and viremia class.
Table 5.
Odds ratios of the cross protectivity of neutralising antibodies (nAbs) from individuals from profile Class 1 relative to that of nAbs from individuals from viremia profile Class 2.