Table 1.
CSF biochemical values from subjects with CNS infections and peripheral infections.
Table 2.
Patients with CSF neopterin levels above 61/l (n = 56).
Table 3.
Patients with CSF neopterin levels below 61/l (n = 550).
Figure 1.
ROC curve to determine the new CSF neopterin cut-off.
The samples were classified into two groups according to the condition that they presented either bacterial/viral central infection (n = 68) or peripheral infection (n = 52). The area under the curve was 0.934 (range: 0.883–0.985) with 61 nmol/l as the new cut-off. The sensitivity was 91.3%, and the specificity was 88.5%.
Figure 2.
Representation of the 606 neurological patients in the clinical groups.
Each group shows the percentage of patients with high CSF WBC, high CSF proteins and high CSF neopterin. The inflammatory/immune-mediated group had a significantly elevated percentage of high CSF WBC (*X2 = 27.91, p<0.001), high CSF proteins (ΨX2 = 17.51, p<0.001) and high CSF NP (ΦX2 = 103.73, p<0.001) compared with the other groups.