Figure 1.
3D structure of the homology model of the human ClC-1 dimer (transmembrane domains are in blue and gray) with the Cl- channel (in green) visualized in one subunit.
A shows highlighted interface and the channel with the key amino acid Glu 232 (red surface) and two Cl- ions (yellow balls) which were superimposed from the original X-ray structure of the CmClC transporter. B shows 6 new missense mutations mapped in one subunit.