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Figure 1.

Role of cytokines and other determinants in chemotherapy-induced cognitive impairment.

Multiple factors have been postulated as determinants of cognitive changes in cancer patients, including demographical, physiological, psychological, pathological and pharmacological determinants. Recent experimental studies have suggested that pro-inflammatory cytokines may be mediators of chemotherapy-associated cognitive changes.

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Figure 2.

Results of Literature Search.

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Table 1.

Summary of methods and results from selected studies (Studies are listed in alphabetical order).

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Table 2.

Recommended methodological guidelines for future studies.

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Table 3.

Summary of potential research questions.

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